Role of Capsaicin in Oxidative Stress and Cancer


Role of Capsaicin in Oxidative Stress and Cancer
Sanjay K. Srivastava - Role of Capsaicin in Oxidative Stress and Cancer
Published: 2013-04-24 | ISBN: 9400763166, 9401784299 | PDF | 178 pages | 3.45 MB

This book describes the mechanism of the anti-cancer effects of capsaicin including the involvement of cytochrome P-450 in the bioactivation; identification of mitochondria as the key target site for oxidative stress; involvement of mitochondrial respiratory chain in the production of ROS; prevention of chemically-induced carcinogenesis, discussion on TRPV-1 receptor mediated or independent anti-cancer effects; identification of p53 activation as a possible mechanism; involvement of Cox-2 in apoptosis, suppression of transcrion factors such as NF-kB and STAT-3; inhibition of cell survival pathways including PI3K/Akt and the involvement of intrinsic mitochondrial cell death pathway.


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