Computational Modelling of the Human Islet Amyloid Polypeptide

Computational Modelling of the Human Islet Amyloid Polypeptide
Springer | Chemistry | June 9, 2016 | ISBN-10: 3319200399 | 118 pages | pdf | 4.45 mb

Authors: Skeby, Katrine Kirkeby
Nominated as an outstanding PhD thesis by Aarhus University, Denmark
Provides a comprehensive review of the general amyloid literature, in particular that on human islet amyloid polypeptide
Includes detailed illustrations, which significantly aid in the understanding of amyloid proteins and the research presented
Combines theoretical and experimental research to deliver a high-impact, high-quality contribution

This thesis offers readers a comprehensive introduction to amyloid proteins and the computational methods used with them. Katrine Skeby critically assesses and compares both the literature and the experiments performed by other researchers, which further elevates the quality and relevance of her own work. Amyloid proteins are highly complex, and this research provides unparalleled insights, especially with regard to the origin of cytotoxicity and to developing technologies for early detection, revealing in detail the molecular mechanisms behind hIAPP behavior. Several studies within the thesis answer difficult questions which promote future research into the properties of amyloid proteins

Number of Illustrations and Tables
11 b/w illustrations, 47 illustrations in colour
Medicinal Chemistry
Computer Applications in Chemistry
Bioorganic Chemistry

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