Optimized Response-Adaptive Clinical Trials: Sequential Treatment Allocation Based on Markov Decision Problems
Optimized Response-Adaptive Clinical Trials: Sequential Treatment Allocation Based on Markov Decision Problems By Thomas Ondra
2015 | 120 Pages | ISBN: 3658083433 | PDF | 2 MB
Two-armed response-adaptive clinical trials are modelled as Markov decision problems to pursue two overriding objectives: Firstly, to identify the superior treatment at the end of the trial and, secondly, to keep the number of patients receiving the inferior treatment small. Such clinical trial designs are very important, especially for rare diseases. Thomas Ondra presents the main solution techniques for Markov decision problems and provides a detailed descrion how to obtain optimal allocation sequences.
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